 Structure-based Evolution of G protein-biased
μ-opioid Receptor Agonists | Kobilka, Stanford | 2022 | Bias AgonismExperimental | Angew Chem Int Ed Engl | kobilka_angewandte.pdf | | https://doi.org/10.1002/anie.202200269 |
| Structural Assessment of Agonist Efficacy in the μ-Opioid Receptor: Morphine and Fentanyl Elicit Different Activation Patterns | Giraldo, Barcelona, Spain | 2021 | Ligand Binding | JCIM | | | https://doi.org/10.1021/acs.jcim.0c00890 |
| TRV130 partial agonism and capacity to induce anti-nociceptive tolerance revealed through reducing available
μ-opioid receptor number | Hales, Dundee, UK | 2021 | Bias AgonismExperimental | BPH | | | https://doi.org/10.1111/bph.15409 |
| Molecular insights into the biased signaling mechanism of the μ-opioid receptor | Granier, Nice, France | 2021 | Bias Agonism | Molecular Cell | granier_cell.pdf | | https://doi.org/10.1016/j.molcel.2021.07.033 |
| Structural insights into distinct signaling profiles of the µOR activated by diverse agonists | Dror, Stanford | 2021 | PDB paper | Biorxiv | | | https://doi.org/10.1101/2021.12.07.471645 |
| CHARMM Force-Field Parameters for Morphine, Heroin, and Oliceridine, and Conformational Dynamics of Opioid Drugs | Bondar, Berlin, Germany | 2021 | Force Fields | JCIM | qm.paper.pdf | | https://doi.org/10.1021/acs.jcim.1c00667 |
| How μ-opioid receptor recognizes fentanyl | Shen, UMD | 2021 | Ligand Binding | Nature Comm. | shen_natcomm-combined(edited-Smallpdf).pdf | | https://doi.org/10.1038/s41467-021-21262-9 |
| Kinetics and Mechanism of Fentanyl Dissociation from the MOR | Shen, UMD | 2021 | Ligand Binding | JACS Au | | | https://doi.org/10.1021/jacsau.1c00341 |
| Mechanism of μ-Opioid Receptor-Magnesium Interaction and Positive Allosteric Modulation | Filizola, Mount Sinai | 2020 | Allosteric Modulators | Biophysical Journal | | | https://doi.org/10.1016/j.bpj.2019.10.007 |
| Structure and Dynamics of GPCRs in Lipid Membranes: Physical Principles and Experimental Approaches | Nietlispach, Cambridge | 2020 | CholesterolLipidsReview | molecules MDPI | | | https://doi.org/10.3390/molecules25204729 |
| Mechanism of β-arrestin recruitment by the µ-opioid G protein-coupled receptor | Goddard, Caltech | 2020 | Bias Agonism | PNAS | goddard_pnas (1).pdf | | https://doi.org/10.1073/pnas.1918264117 |
| A tetrapeptide class of biased analgesics from an Australian fungus targets the µ-opioid receptor | Christie, Australia | 2019 | Bias Agonism | PNAS | | | https://doi.org/10.1073/pnas.1908662116 |
| In silico studies of conformational dynamics of Mu opioid receptor performed using gaussian accelerated molecular dynamics | Wang, Taiwan | 2019 | Conformational ChangesEnhanced Sampling | J Biomol Struct Dyn. | | | https://doi.org/10.1080/07391102.2017.1422025 |
| Diverse GPCR exhibit conserved water networks for stabilization and activation | Dror, Stanford | 2019 | Waters | PNAS | dror_pnas.pdf | | https://doi.org/10.1073/pnas.1809251116 |
| Molecular dynamics of fentanyl bound to μ-opioid receptor | Lipinski, Warsaw, Poland | 2019 | Ligand Binding | J Mol Model | lipinski_jmm(edited-Smallpdf).pdf | | https://doi.org/10.1007/s00894-019-3999-2 |
| Kinetic and thermodynamic insights into sodium ion translocation through the μ-opioid receptor from molecular dynamics and machine learning analysis | Filizola, Mount Sinai | 2019 | Allosteric Modulators | PLOS | filizola_plos.pdf | | https://doi.org/10.1371/journal.pcbi.1006689 |
| Drug Binding Poses Relate Structure with Efficacy in the μ Opioid Receptor | Sutcliffe, Bristol, UK | 2017 | Activation MechanismLigand Binding | JMB | sutcliffe_jmb.pdf | | https://doi.org/10.1016/j.jmb.2017.05.009 |
| The Mechanism of Ligand-Induced Activation or Inhibition of MOR and KOR | Yuan, Switzerland | 2015 | Activation MechanismLigand Binding | Angew Chem Int Ed Engl | | | https://doi.org/10.1002/anie.201501742 |
| Structural Determinants for the Binding of Morphinan Agonists to the μ-Opioid Receptor | Filizola, Mount Sinai | 2015 | Ligand Binding | PLOS | | | https://doi.org/10.1371/journal.pone.0135998 |
| Activation and Allosteric Modulation of Human μ Opioid Receptor in Molecular Dynamics | Bartuzi, Poland | 2015 | Allosteric ModulatorsLigand BindingLipids | JCIM | bartuzi_jcim.pdf | | https://doi.org/10.1021/acs.jcim.5b00280 |
| A G protein-biased ligand at the μ-opioid receptor is potently analgesic with reduced gastrointestinal and respiratory dysfunction compared with morphine | Violin, Trevena Inc., PA | 2013 | Bias AgonismExperimental | JPET | | | http://dx.doi.org/10.1124/jpet.112.201616 |
| The Role of Water and Sodium Ions in the Activation of MOR | Yuan, Switzerland | 2013 | Activation MechanismAllosteric Modulators | Angew Chem Int Ed Engl | | | https://doi.org/10.1002/anie.201302244 |
